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Persistent exposure to large amounts of LPS leads to the development of many lung diseases, including asthma. To date, we do not fully understand what genetic factors contribute to exposure to asthma. So, this study aims to identify the molecular and immune mechanisms of asthma developed with LPS by targeting specific transcription factors that regulate SHH activity levels.

Objectives of the project:

1. Determination of the impact of exposure to LPS on the development of asthma in animals.
2. Determine the function of transcription factors in the pathological development of asthma and their interaction with the SHH pathway.
3. Determining the effect of exposure to LPS on the phenotype and immune cell function in inflammatory foci. This study will determine the role of transcription factors as an influential factor in the development and worsening of asthma. It may thus help to design future strategies to prevent the worsening and treatment of asthma, as well as possible means of screening to determine the genetic susceptibility of patients with asthma in Egypt. This will certainly help to solve a major problem affecting both human health and the economy in Egypt.