Description

URL

https://www.tandfonline.com/doi/full/10.1080/22243682.2017.1296370

DOI

https://doi.org/10.1080/22243682.2017.1296370

Brief

Copper complexes of Schiff-bases of metformin with each of salicylaldehyde (HL1); 2,3-dihydroxybenzaldehyde (H2L2); 2,4-dihydroxybenzaldehyde (H2L3); 2,5-dihydroxybenzaldehyde (H2L4); 3,4-dihydroxybenzaldehyde (H2L5) and o-hydroxynaphthaldehyde (HL6) were synthesized by template reaction. The new compounds are characterized through elemental analysis, conductivity measurements, magnetic moment, IR, UV–Vis, NMR, ESR, Mass spectroscopy, TEM and molecular modeling. The complexes have square pyramidal structure with magnetic moment values of 1.96–1.81 B.M. and dx2−y2 ground state. TGA, DTG and DTA analysis confirm the proposed stereochemistry. Thermodynamic parameters are calculated for the second and third decomposition steps. The complexes [CuL1(H2O)2].2H2O, [CuL4(H2O)2].2H2O and [CuL5OH(H2O)2].3H2O are evaluated for their hypoglycemic activity in alloxan-induced diabetic mice and have shown toxicity at doses of 20 and 40 mg/kg.

KeyWords

Metformin Schiff-base, copper complexes, spectral and thermal analysis, toxicity effect