Description

URL

https://link.springer.com/article/10.1007/s10973-016-6018-1

DOI

http://dx.doi.org/10.1007/s10973-016-6018-1

Brief

A series of VO2+ complexes of Schiff-bases of metformin with each of salicylaldehyde (HL1); 2,3-dihydroxybenzaldehyde (H2L2); 2,4-dihydroxybenzaldehyde (H2L3); 2,5-dihydroxybenzaldehyde (H2L4); 3,4-dihydroxybenzaldehyde (H2L5); and 2-hydroxynaphthaldehyde (HL6) were synthesized by template reaction. The new compounds are characterized through elemental analysis, conductivity measurements, magnetic moment, IR, UV–Vis, ESR and mass spectroscopy. The complexes have square pyramidal structure with μ values of penta coordinated vanadyl ion. TG, DTG and DTA confirm the proposed stereochemistry, and a mechanism of thermal decomposition was suggested. Mice treated with the complexes [VOL1H2O]·1½H2O and [VOHL4H2O]·2H2O showed glucose-lowering effect of 59.31, 58.79% (20 mg kg−1) and 64.98, 74.8% (40 mg kg−1) compared to metformin.

KeyWords

Keywords: Metformin Schiff-bases. VO2+ complexes. Spectral and thermal properties. Antidiabetes mellitus