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Publish Date
6/11/2019 12:00:00 AM
144
Authors
Description
Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis. Study Design: Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017. Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results. Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs.
URL
https://www.researchgate.net/publication/333708957_Non-traditional_Route_for_Three_Antifungal_Drugs_in_Fungal_Keratitis_Treatment
DOI
10.9734/or/2019/v10i230104
Brief
Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.
KeyWords
Fungal keratitis, intrastromal injection, antifungal drugs, fluconazole, amphotericin B, voriconazole.